當前位置：
科學研究>
科研團隊本團隊聚焦天然藥物，開展生物活性、結構修飾、新型制劑等研究，針對癌癥、綜合代謝癥、炎癥、皮膚病、蚊媒傳染病等疾病，進行新藥品、保健食品、功能美容化妝品和公共衛生產品的開發與轉化。
趙登高，博士，副教授，主要從事天然藥物的發現、結構修飾和改造以及蛋白降解劑等研究，先后承擔多項國家級和省部級項目，以第一或者通訊作者身份發表SCI論文30余篇。
代表論文
（1） Mo, H.; Liu, J.; Yin, T.; Cao, X.; Su, Z.; Zhao, D.-G.*; Ma, Y.-Y.*, Discovery of a Selective and Orally Bioavailable RET Degrader with Effectiveness in Various Mutations. J. Med. Chem. 2025, 68, 2657?2679.
（2） Zhao, D. G.*; Liu, J.; Su, Z.; Zou, W.; Zhou, Q.; Yin, T.; Jiyao, T.; Ma, Y. Y., * Discovery of novel KSP-targeting PROTACs with potent antitumor effects in vitro and in vivo. Euro. J. Med. Chem. 2025, 282, 117052.
（3） Mo, H.; Liu, J.; Su, Z.; Zhao, D. G. *; Ma, Y. Y. *; Zhang, K.; Wang, Q.; Fu, C.; Wang, Y.; Chen, M.; Hu, B. *, Isoalantolactone/hydroxamic acid hybrids as potent dual STAT3/HDAC inhibitors and self-assembled nanoparticles for cancer therapy. Eur J Med Chem 2024, 277, 116765. 2024.8
（4） Mo, H.; Zhang, R.; Chen, Y.; Li, S.; Wang, Y.; Zou, W.; Lin, Q.; Zhao, D.-G. *; Du, Y. *; Zhang, K.; Ma, Y. Y. *, Synthesis and anticancer activity of novel histone deacetylase inhibitors that inhibit autophagy and induce apoptosis. Euro. J. Med. Chem. 2022, 114705.
（5） Zhang, R.; Mo, H.; Ma, Y. Y.; Zhao, D. G. *; Zhang, K.; Zhang, T.; Chen, X.; Zheng, X., Synthesis and structure-activity relationships of 5-phenyloxazole-2-carboxylic acid derivatives as novel inhibitors of tubulin polymerization. Bioorg Med Chem Lett 2021, 40, 127968.
馬燕燕，博士，副教授，主要從事天然藥物活性成分的提取分離、結構鑒定、藥理活性研究以及功能產品的研發，先后承擔多項國家級和省部級項目，以第一或者通訊作者身份發表SCI論文20余篇。
（1）Xu, D.; Chen, Y.; Cao, X.-X.; Zheng, J.; Wang, Y.; Ma, Y.-Y. *; Zhang, K.; Zhao, D.-G., Anti-inflammatory activity of phenolics from Dianella ensifolia. Phytochem. Lett. 2024, 61, 187-190.
（2）Li, S.; Xu, D.; Jia, J.; Zou, W.; Liu, J.; Wang, Y.; Zhang, K.; Zheng, X.; Ma, Y. Y. *; Zhang, X.; Zhao, D. G., Structure and anti-inflammatory activity of neo-clerodane diterpenoids from Scutellaria barbata. Phytochemistry 2023, 213, 113771.
（3）Li, X.; Xu, Dan.; Liu, J.; Ma, Y.-Y.; * Zhao, D.-G.; * Zhang, K. Anti-inflammatory activity of phenolics from Hypericum japonicum. Phytochem. Lett. 2023, 55, 156-159.
（4）He, X.; Zhang, M.; Li, S. T.; Li, X.; Huang, Q.; Zhang, K.; Zheng, X.; Xu, X. T.; Zhao, D. G.; Ma, Y. Y., Alteration of gut microbiota in high-fat diet-induced obese mice using carnosic acid from rosemary. Food Sci. Nutr. 2022, 10 (7), 2325-2332.
（5）Ma, Y. Y.; Zhao, D. G.; Zhang, R.; He, X.; Li, B. Q.; Zhang, X. Z.; Wang, Z.; Zhang, K. *, Identification of bioactive compounds that contribute to the alpha-glucosidase inhibitory activity of rosemary. Food Funct. 2020, 11 (2), 1692-1701.
盛釗君，博士，副教授。2014年博士畢業于法國巴黎第七大學藥物化學專業，2017年和2023年先后兩次在英國利物浦熱帶醫學院訪學。目前主要從事植物來源的蚊蟲驅避、誘引、滅殺活性成分的篩選、機理研究及緩釋劑型開發，主持20余項各類科研項目，以第一或者通訊作者身份在SCI期刊上發表論文16篇。
代表論文
（1）Siyuan Ge, Rongchao Jian, Qiwei Xuan, Yingxiang Zhu, Xiaofei Ren, Wenjiao Li, Xiaole Chen, Ruikang Huang, Chi-Sing Lee, Suet. Leung, Nicoletta Basilico, Silvia Parapini, Donatella Taramelli, Nattapon Pinthong, Svetlana V. Antonyuk, Paul M. O’Neill, Zhaojun Sheng*, W. David Hong*. Novel antimalarial 3-substituted quinolones isosteres with improved pharmacokinetic properties. European Journal of Medicinal Chemistry, 2025, 284, 117228. DOI: 10.1016/j.ejmech.2024.117228
（2）Yuling Li, Jialun Zou, Xiaofei Ren, Wenjiao Li, Weifeng Wu, Qiwei Xuan, Hanwen Miao, Yajie Chen, Chi-Sing Lee, Zhaojun Sheng*. Discovery of α-hexyl cinnamaldehyde and its derivatives as novel larvicides against Aedes albopictus. Arabian Journal of Chemistry, 2024, 17 (9), 105873. DOI: 10.1016/j.arabjc.2024.105873
（3）Yuling Li, Weifeng Wu, Rongchao Jian, Xiaofei Ren, Xiaole Chen, Weiqian David Hong, Min Wu, Jinglin Cai, Canyao Lao, Ximing Xu, Zhaojun Sheng*. Larvicidal, acetylcholinesterase inhibitory activities of four essential oils and their constituents against Aedes albopictus, and nanoemulsion preparation, Journal of Pest Science, 2023, 96: 961-971. DOI: 10.1007/s10340-022-01555-8
（4）Weifeng Wu, Yu Yang, Yingmiao Feng, Xiaofei Ren, Yuling Li, Wenjiao Li, Jietong Huang, Lingjia Kong, Xiaole Chen, Zhongze Lin, Xiaohui Hou, Longlai Zhang, Yajie Chen, Zhaojun Sheng*, Weiqian Hong*. Study of the repellent activity of 60 essential oils and their main constituents against Aedes albopictus, and nano-formulation development, Insects, 2022, 13, 1077. DOI: 10.3390/insects13121077
（5）Zhaojun Sheng, Rongchao Jian, Fangying Xie, Bin Chen, Kun Zhang, Dongli Li, Wenhua Chen, Chiguang Huang, Yan Zhang, Litao Hu, Denggao Zhao, Xi Zheng, Panpan Wu*, Weiqian David Hong. Screening of larvicidal activity of 53 essential oils and their synergistic effect for the improvement of deltamethrin efficacy against Aedes albopictus, Industrial Crops and Products, 2020, 145, 112131. DOI: 10.1016/j.indcrop.2020.112131
陳靜，博士，講師，主要從事抗腫瘤藥物的靶向遞送、新型納米材料研究及納米給藥系統在腫瘤靶向免疫治療中的應用。先后承擔多項科研項目，以第一或者通訊作者身份發表SCI論文10余篇。
代表論文
（1）Yuan Lin, Chuangnan Li, Kaijie Cen, Jucai Xu, Jing Chen. Fabrication, characterization, and in vitro biological evaluation of glycyrrhetinic acid ligand-functionalized proliposomes encapsulated docetaxel for treatment of hepatocellular carcinoma. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2025, 707, 135802. (本人為通訊作者）
（2）Liuping Chen, Zhijun Chen, Guo Sien, Haifeng Yang, Yanjiao Liu, Xiaoling Chen, Huiqi Chen, Xinming Chen, Tingting Du, Xinyao Long, Jiaxiong Zhao, Mingli Guo, Lei Wang, Jing Chen, Chunping Liu. Psoriasis Comorbid with Atherosclerosis meets in Lipid Metabolism. Frontiers in Pharmacology, 2023, 12 (10)，105131-151142 （本人為共同通訊作者）
（3）Yuan Lin, Yimin Zhang, Zhuang Xiong, Mi Wu, Muling Zeng, Chuangnan Li, Fujin Liu, Yazhi Liao, Chunping Liu, Jing Chen. Development of glycyrrhetinic acid ligand-functionalized liposomes for targeting hepatocellular carcinoma: Synthesis, preparation, characterization, and evaluation. Arabian Journal of Chemistry, 2023, 16, 105131-105142. （本人為通訊作者）
（4）Jing Chen, Yuan Lin, Min Wu, Chuangnan Li, Kaijie Cen, Fujin Liu, Yazhi Liao, Xiaoqing Zhou, Jucai Xu, Yi Cheng. Glycyrrhetinic acid proliposomes mediated by mannosylated ligand: Preparation, physicochemical characterization, environmental stability and bioactivity evaluation, Colloids and Surfaces B: Biointerfaces, 2022, 218, 112781-112790.（本人為一作及通訊作者）
（5）Chunping Liu, Jing Chen, Huiqi Chen, Tong Zhang, Dongyue He, Qiyuan Luo, Jiaxin Chi, Zebin Hong, Yizhong Liao, Shihui Zhang, Qizhe Wu, Huan Cen, Guangzhong Chen, Jinxin Li, Lei Wang. PCSK9 Inhibition: From Current Advances to Evolving Future. Cells, 2022, 11, 2972-2999. （本人為共同第一作者）
（6）Rongchao Jian, Yuan Lin, Yuling Li, Weifeng Wu, Xiaofei Ren, Zhanyuan Liang, Lingjia Cai, Canyao Lao, Min Wu, Wenhua Chen, Jing Chen, Weiqian David Hong, Zhaojun Sheng. Larvicidal activity of two Rutaceae plant essential oils and their constituents against Aedes albopictus in multiple formulations, Journal of Medical Entomology, 2022, 59(5), 1669-1677.（本人為共同通訊作者）
（7）Yuan Lin, Xin Kang Li, Jia Ying Yan, Ying Lin Lei, Jing Chen, Bao Qiong Li. EEFM combined with N-PLS method for the quantitative determination of psoralen in cosmetics. Chemical Papers, 2022, 76: 5819-5825.（本人為共同通訊作者）
（8） Jing Chen, Yuan Lin, Min Wu, Chuangnan Li, Yimin Zhang, Dongpeng Chen, Yi Cheng. Drug-Free Liposomes Containing Mannosylated Ligand for Liver-Targeting: Synthetic Optimization, Liposomal Preparation, and Bioactivity Evaluation, Journal of Biomedical nanotechnology, 2021, 17(12): 2455-2465.（本人為一作并通訊）
團隊成員 | ||
|
|
|
| ||
