基本情況
陳國棟，研究員，博士生導師，入選廣東省教育廳珠江學者特聘教授、廣東省自然科學基金杰出青年、廣州市珠江科技新星，長期以中藥及植物內生真菌作為研究對象，開展中藥物質基礎、候選藥物分子發現以及污染中藥材真菌毒素研究。
目前以第一/共同第一或共同通訊作者身份發表SCI論文39篇，包括Nat Comm、Acta Pharm Sin B、Org Lett、Chem Comm 等top期刊8篇，申請授權發明專利13個，其中3個為國外專利?，F擔任廣東省藥學學會藥物手性專業委員會副主任委員、中國菌物學會菌物化學專委會委員以及《Chinese Chemical Letters》青年編委會委員。同時不斷落實教書育人立德樹人根本任務，主持項1項廣東省高等教育教學改革項目并在擔任教工黨支部書記期間，以“一核心兩強化三融合”開展“錘煉黨性，涵養師德”黨建工作，入選教育部首屆全國高?！半p帶頭人”教師黨支部書記工作室、教育部全國黨建工作樣板支部和廣東省黨建工作樣板支部。
聯系方式
地址：廣東省江門市蓬江區東成村22號 五邑大學藥學與食品工程學院
郵編：529020
郵箱：chgdtong@163.com
近五年主持的科研項目
1. 國家自然科學基金面上基金項目(81973213) “基于活潑中間體驅動策略的苔色酸二聚體多樣庫構建及其神經保護的構效和機制研究” (2020-2023，56萬元，在研)。
2. 國家自然科學基金面上基金項目(81673315) “基于多靶點抗阿爾茨海默癥的多節孢綠膠霉素類化合物的優選與作用機制研究” (2017-2020，52萬元，在研)。
3. 國家重點研發計劃項目(2018YFC0311003) “海洋微生物候選藥物的高效發現與創制”項目子課題 (2018-2021，27.8萬元，在研)。
4. 廣東省自然科學杰出青年基金項目(2017A03036027) “地衣內生真菌中抗老年癡呆活性成分的發現及其作用機制研究” (2017-2021, 100萬元，在研)。
廣州市珠江科技新星項目(201610010021) “地衣內生真菌中抗AD活性成分研究” (2016-2019, 30萬元，結題)。
近五年發表代表性論文
[1] Huang Hui-Yun, Huang Jia-Hua, Wang Yong-Heng, Hu Dan, Lu Yong-Jun, She Zhi-Gang, Chen Guo-Dong*, Yao Xin-Sheng, Gao Hao*. The oxidation cascade of a rare multifunctional P450 enzyme involved in asperterpenoid A biosynthesis. Frontiers in Chemistry, 2021, 9, 785431.
[2] Zhao Huan, § Zou Jian, § Xu Wei, Hu Dan, Guo Liang-Dong, Chen Jia-Xu, Chen Guo-Dong,* So Kwok-Fai, Yao Xin-Sheng, Gao Hao.* Diisoprenyl-cyclohexene/ane-type meroterpenoids from Biscogniauxia sp. and their anti-inflammatory activities. Journal of Organic Chemistry, 2021, 86, 11177-11188.
[3] Chen Guo-Dong,§ Zhao Bing-Xin,§ Huang Mei-Juan, Tang Jia, Li Yan-Bing, Guo Liang-Dong, He Rong-Rong, Hu Dan,* Yao Xin-Sheng, Gao Hao.* Tripodalsporormielones A–C, unprecedented cage-like polyketides with complex polyvdent bridged and fused ring systems. Acta Pharmaceutica Sinica B, 2021, 11, 3648-3654.
[4] Tian Dan-Mei, Cao Ling-Yun, Li Qing-Wen, Huang Hui-Yun, Xu Wei, Chen Guo-Dong*, Song Zhao-Hui, He Yi, Yao Xin-Sheng, Tang Jin-Shan*. Benzannulated 5,5-spiroketal sesquiterpenes from the roots of Angelica pubescens. Bioorganic Chemistry, 2021, 107, 104604.
[5] Chen Guo-Dong, Hu Dan, Gao Hao, Yao Xin-Sheng*. The importance of researches on the fungal bioactive secondary metabolites in developing the comprehensive health industry. Chinese Journal of Natural Medicines, 2020, 18, 241-242.
[6] Chen Guo-Dong§, Hu Dan§, Huang Mei-Juan§, Tang Jia, Wang Xiao-Xia, Zou Jian, Xie Jun, Zhang Wei-Guang, Guo Liang-Dong, Yao Xin-Sheng*, Abe Ikuro*, Gao Hao*. Sporormielones A–E, bioactive novel C-C coupled orsellinic acid derivative dimers, and their biosynthetic origin. Chemical Communications, 2020, 56, 4607-4610. (§co-first author)
[7] Chen Guo-Dong, Wang Chuan-Xi, Hu Dan, Gao Hao, Yao Xin-Sheng*. Discovery of new metabolites from fungi in special habits and their biological function evaluations. Toxicon, 2019, 158, S29-S29.
[8] Zou Jian§, Chen Guo-Dong§, Zhao Huan, Wang Xiao-Xia, Zhang Zai-Jun, Qu Yi-Bo, He Rong-Rong, So Kwok-Fai, Yao Xin-Sheng, Gao Hao*. Triangeliphthalides A-D: bioactive phthalide trimers with new skeletons from Angelica sinensis and their production mechanism. Chemical Communications, 2019, 55, 6221-6224. (§co-first author)
[9] Zhao Huan§, Wang Mei-Zhi§, Chen Guo-Dong*, Hu Dan, Li En-Qing, Qu Yi-Bo, Zhou Li-Bing, Guo Liang-Dong, Yao Xin-Sheng, Gao Hao*. Dimericbiscognienynes B and C: new diisoprenyl-cyclohexene-type meroterpenoid dimers from Biscogniauxia sp. Chinese Chemical Letters, 2019, 30, 51-54.
[10] Wang Gao-Qian§, Chen Guo-Dong§, Qin Sheng-Ying§, Hu Dan*, Awakawa Takayoshi, Li Shao-Yang, Lv Jian-Ming, Wang Chuan-Xi, Abe Ikuro*, Gao Hao*. Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage. Nature Communications, 2018, 9, 1838 (§co-first author)
[11] Zou Jian§, Chen Guo-Dong§, Zhao Huan, Huang Ying, Luo Xiang, Xu Wei, He Rong-Rong, Hu Dan, Yao Xin-Sheng, Gao Hao*. Triligustilides A and B: Two pairs of phthalide trimers from Angelica sinensis with a complex polycyclic skeleton and their activities. Organic Letters, 2018, 20, 884-887 (§co-first author)
[12] Li Jiao-Jiao§, Chen Guo-Dong§, Fan Hong-Xia, Hu Dan, Zhou Zheng-Qun, Lan Kang-Hua, Zhang Hui-Ping, Maeda Hideaki, Yao Xing-Sheng, Gao Hao*. Houttuynoid M, an anti-HSV active houttuynoid from Houttuynia cordata featuring a bis-houttuynin chain tethered to a flavonoid core. Journal of Natural Products, 2017, 80, 3010-3013 (§co-first author)
[13] Zhao Huan§, Chen Guo-Dong§, Zou Jian, He Rong-Rong, Qin Sheng-Ying, Hu Dan, Li Guo-Qiang, Guo Liang-Dong, Yao Xin-Sheng*, Gao Hao*. Dimericbiscognienyne A: A meroterpenoid dimer from Biscogniauxia sp. with new skeleton and its activity. Organic Letters, 2017, 19, 38-41 (§co-first author)
[14] Sun Tian-Yu, Zou Jian, Chen Guo-Dong*, Hu Dan, Wu Bin, Liu Xing-Zhong, Yao Xin-Sheng, Gao Hao*. A set of interesting sequoiatone stereoisomers from a wetland soil-derived fungus Talaromyces flavus. Acta Pharmaceutica Sinica B, 2017, 7, 167-172.
[15] Wang Chuan-Xi§, Chen Guo-Dong§, Feng Chun-Chi, He Rong-Rong, Qin Sheng-Ying, Hu Dan, Chen He-Ru, Liu Xing-Zhong, Yao Xin-Sheng*, Gao, Hao*. Same data, different structures: diastereoisomers with substantially identical NMR data from nature. Chemical Communications, 2016, 52, 1250-1253 (§co-first author)
申請專利
[1] 姚新生，洪葵，李佳，高昊，唐金山，林海鵬，高立信，陳國棟，謝晴宜，盛麗. 一種芳香類化合物作為制備Caspase 3 抑制劑的用途. (ZL 201010230402.2)
[2] 高昊，姚新生，鄭易之，郭良棟，陳國棟，孫翔，鄭啟昌，孔明珠，李小霞. 脫甲綠膠酶素在制備β-淀粉樣蛋白聚集抑制劑中的用途. (201310196180.0)
[3] 高昊，姚新生，鄭易之，陳國棟，郭良棟，孫翔，趙歡，李小霞，孔明珠. 聯苯醚類化合物在制備β-淀粉樣蛋白聚集抑制劑中的用途. (ZL201410332005.4)
[4] 高昊，陳國棟，姚新生，郭良棟，胡丹，于洋，趙琴，馮曉琳，李小霞，王高乾. 裂環多節孢綠膠霉素類化合物及其用途. (ZL201510111322.8)
[5] 高昊，陳國棟，姚新生，郭良棟，胡丹，于洋，趙琴，馮曉琳，李小霞，王高乾. 多節孢綠膠霉素E及其用途. (ZL 201510112075.3)
[6] 高昊，陳國棟，姚新生，郭良棟，胡丹，于洋，趙琴，馮曉琳，李小霞，王高乾. 多節孢綠膠霉素類化合物及其用途. (ZL 201510112090.8)
[7] 高昊，陳國棟，姚新生，趙歡，郭良棟，胡丹，王傳喜，秦盛瑩，鄒劍. 二聚炭皮烯炔A及其在制備預防和治療神經退行性疾病藥物中的應用. (ZL201611101694.3)
[8] 高昊，陳國棟，姚新生，趙歡，郭良棟，胡丹，王傳喜，秦盛瑩，鄒劍. 炭皮酸A及其在制備預防和治療神經退行性疾病藥物中的應用. (ZL201611101594.0)
[9] 高昊，姚新生，何蓉蓉，李藥蘭，陳國棟，周正群，王傳喜，李滿妹，胡丹，范紅霞. 一種二咖啡酰亞精胺衍生物糖苷及其用途. (ZL201610032769.0、PCT/CN2017/071119)
[10] 高昊，姚新生，何蓉蓉，陳國棟，周正群，王傳喜，胡丹，范紅霞. 一種二咖啡酰亞精胺環化衍生物及其用途. (ZL201610033609.8、PCT/CN2017/071116)
[11] 高昊，胡丹，陳國棟，姚新生，秦盛瑩，王高乾，呂建明，李韶陽. 甾體化合物側鏈修飾基因及其應用. (ZL201810335957.X)
[12] 陳國棟、趙歡、胡丹、王傳喜、代萍、劉妍穎、高昊、姚新生. 一種炭皮苯酞類化合物、組合物、制備方法及其用途. (ZL 201910418547.6)
[13] 胡丹、韓雪、王傳喜、高昊、姚新生、陳國棟、代萍、張潔. 一種吲哚二萜生物堿類化合物、組合物及其制備方法和用途. (ZL 201910495789.5)
[14] 高昊、陳國棟、姚新生、胡丹、代萍、唐佳、黃美娟.莢孢腔酮類化合物及其制備方法和用途. (ZL202010165727.0)
[15] 陳國棟、高昊、胡丹、姚新生、代萍、黃美娟. 三橋環莢孢腔酮類化合物及其制備方法和用途. (202110390198.9)
