基本情況
鄒慶劍,男,四川成都人。現任五邑大學藥學與食品工程學院專任教師。
聯系方式
地址:廣東省江門市蓬江區東成村22號 五邑大學藥學與食品工程學院
郵編:529020
郵箱:wyuchemzqj@126.com
工作經歷
2018年5月至今,五邑大學,藥學與食品工程學院,碩士生導師
2016年7月至2018年5月,天津天銳生物科技有限公司,研發總監
2013年7月至2018年6月,中國科學院廣州生物醫藥與健康研究院,研究助理
教育及學習經歷
2007年9月-2013年 6月,中國科學技術大學生命科學學院,碩士、博士
2002年9月-2006年6月,四川農業大學生命科學學院,學士
主要研究方向
基因治療與干細胞治療,基因編輯大動物模型構建與疾病治療研究
發表學術論文
1. Liu, Y., Zhou, J., Lan, T., Zhou, X., Yang, Y., Li, C., Zhang, Q., Chen, M., Wei, S., Zheng, S., Cheng, L., Zheng, Y., Lai, L., and Zou, Q. (2022) Elimination of Cas9-dependent off-targeting of adenine base editor by using TALE to separately guide deaminase to target sites. Cell Discov 8, 28(通訊作者)【IF=38.1】
2. Zhou, J., Liu, Y., Wei, Y., Zheng, S., Gou, S., Chen, T., Yang, Y., Lan, T., Chen, M., Liao, Y., Zhang, Q., Tang, C., Liu, Y., Wu, Y., Peng, X., Gao, M., Wang, J., Zhang, K., Lai, L., and Zou, Q. (2022) Eliminating predictable DNA off-target effects of cytosine base editor by using dual guiders including sgRNA and TALE. Mol Ther (通訊作者)【IF=12.9】
3. Lan, T., Chen, H., Tang, C., Wei, Y., Liu, Y., Zhou, J., Zhuang, Z., Zhang, Q., Chen, M., Zhou, X., et al. (2023). Mini-PE, a prime editor with compact Cas9 and truncated reverse transcriptase. Mol Ther Nucleic Acids 33, 890-897. (通訊作者)【IF=10.8】
4. Chen, M., Wang, X., Li, C., Lan, T., Wei, Y., Tang, C., Zhou, X., Zhou, R., Rosa, A., Zheng, X., Ang, S., Zhang, K., Zou, Q., and Lai, L. (2022) Inducible motor neuron differentiation of human induced pluripotent stem cells in vivo. Cell Prolif, e13319(通訊作者)【IF=8.7】
5. Liu, Y., Yang, Y., Suo, Y., Li, C., Chen, M., Zheng, S., Li, H., Tang, C., Fan, N., Lan, T., Zhou, J., Li, Y., Wang, J., Chen, H., Zou, Q., and Lai, L. (2022) Inducible caspase-9 suicide gene under control of endogenous oct4 to safeguard mouse and human pluripotent stem cell therapy. Mol Ther Methods Clin Dev 24, 332-341(通訊作者)【IF=6.7】
6. Lan, T., Zheng, Y., Suo, Y., Wei, Y., Shi, H., Yan, Q., Zhuang, Z., Chen, H., Zhang, Q., Fan, N., Zhao, Y., Ouyang, Z., Lai, C., Liu, Z., Zhou, J., Tang, C., Kim, N. H., Zou, Q., and Wang, X. (2022) Generation of pigs with humanized type II collagen by precise human COL2A1 gene knock-in. J Genet Genomics (通訊作者)【IF=5.8】
7. Zheng S, Zhong H, Zhou X, Chen M, Li W, Zi Y, Chi Y, Wang J, Zheng W, Zou Q, Lai L, Tang C. (2022). Efficient and Safe Editing of Porcine Endogenous Retrovirus Genomes by Multiple-Site Base-Editing Editor. Cells. 【IF=7.5】(通訊作者)
8. Wu Y, Peng X, Ang S, Gao Y, Chi Y, Wang J, Tang C, Zhou X, Feng Y, Zhang K, Zou Q, Chen M. (2023). Bcl-xL Promotes the Survival of Motor Neurons Derived from Neural Stem Cells. Biology (Basel). 【IF=5.1】(通訊作者)
9. Zhou J, Yan Q, Tang C, Liao Y, Zhang Q, Wang X, Zhou X, Lai L, Zou Q. Development of a rabbit model of Wiskott-Aldrich syndrome. FASEB J. 2021 Feb;35(2):e21226 (通訊作者)【IF=5.8】
10. Cheng, L., Zhou, X., Zheng, Y., Tang, C., Liu, Y., Zheng, S., Liu, Y., Zhou, J., Li, C., Chen, M., Lai, L., and Zou, Q. (2021) Simple and Rapid Assembly of TALE Modules Based on the Degeneracy of the Codons and Trimer Repeats. Genes (Basel) 12(通訊作者)【IF=4.5】
11. Li L, Meng H, Zhang J, Liu Y, Zou Q, Gao Y, Yang H, Lai L. A tunable, rapid, and precise drug control of protein expression by combining transcriptional and post-translational regulation systems. J Genet Genomics. 2020 Nov 20;47(11):705-712. (通訊作者)【IF=5.1】
12. Zou, Q., Wang, X., Liu, Y., Ouyang, Z., Long, H., Wei, S., Xin, J., Zhao, B., Lai, S., Shen, J., Ni, Q., Yang, H., Zhong, H., Li, L., Hu, M., Zhang, Q., Zhou, Z., He, J., Yan, Q., Fan, N., Zhao, Y., Liu, Z., Guo, L., Huang, J., Zhang, G., Ying, J., Lai, L., and Gao, X. (2015) Generation of gene-target dogs using CRISPR/Cas9 system. Journal of molecular cell biology 7, 580-583(第一作者)【IF=6.7】
13. Wei, S., Zou, Q., Lai, S., Zhang, Q., Li, L., Yan, Q., Zhou, X., Zhong, H., and Lai, L. (2016) Conversion of embryonic stem cells into extraembryonic lineages by CRISPR-mediated activators. Scientific reports 6, 19648(通訊作者+第一作者)【IF=5.5】
14. Zou, Q., Yan, Q., Zhong, J., Wang, K., Sun, H., Yi, X., and Lai, L. (2014) Direct conversion of human fibroblasts into neuronal restricted progenitors. The Journal of biological chemistry 289, 5250-5260(第一作者)【IF=4.6】
參加學術會議及論文
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申請及授權專利
1. 鄒慶劍;程令印;鄭雨齡;鄭淑文;劉玉;周小青;唐成程;陳敏;賴良學;一種基于密碼子簡并性的快速TALE表達載體構建方法,2021-07-01,申請號: 202110746218.1
2. 鐘慧霖;鄒清雁;劉海霞;鄒慶劍;杜少茵;梁海燕;吳志君;葉俊杰;一種嵌合抗原受體、嵌合抗原受體臍血有核細胞及應用,2020-12-04,申請號:202011411287.9
3. 唐成程;鄒慶劍;周小青;陳敏;賴良學;用于豬MBP基因敲除的sgRNA組合物及用途,2020-06-01,申請號:202010488188.4
4. 陳敏;王霞;周繼曾;陳晃耀;魏愈慧;藍婷;鄒慶劍;周小青;唐成程;張焜;周仁平;賴良學;可定向誘導的、抗凋亡的多能干細胞及其制備方法與應用,2019-10-22,申請號:201911005295.0
5. 周小青;賴良學;鄒慶劍;唐成程;一種提高豬胚胎基因修飾純合子的方法,2020-02-18,申請號:202010100231.5
6. 唐成程;鄭淑文;鄒慶劍;鄭雨齡;李萬勝;周小青;資崯;陳敏;賴良學;識別豬PERV基因的sgRNA及其編碼DNA和應用,2022-01-29,申請號:202210110465.7
7. 周小青;唐成程;鄒慶劍;陳敏;賴良學; 一種可用于異種器官移植的供體豬的構建方法 -2020-08-21,申請號:202010851140.5
8. 賴良學;劉洋;鄒慶劍;周繼曾;周小青;楊洋;李川;劉玉;程令印;鄭雨齡;一種單堿基編輯工具TaC9-ABE及其應用,2021-08-20,申請號: 202110963044.4